The successful candidate will be responsible for designing, implementing, and maintaining Microsoft Azure-based infrastructure, ensuring that the SDE meets stringent security, governance, and compliance requirements associated with clinical research. The role requires experience with cloud platforms, infrastructure as code, and modern DevOps practices, alongside an understanding of networking, monitoring, and system reliability. Experience or interest in the clinical trials or healthcare domain, including the use of informatics and IT to support research, will be highly beneficial.

This position offers the opportunity to contribute to innovative projects in medical research while working in a collaborative and supportive environment. The ideal candidate will demonstrate initiative, creativity, and a genuine interest in applying technology to improve healthcare outcomes, along with strong problem-solving skills and the ability to work both independently and as part of a team.

Closing Date: 13 May 2026

Section: Management, Specialist & Administrative

Salary: £36,636 to £44,746 per annum
Full Time Fixed Term until 30/09/2027

You should have extensive laboratory expertise in cell biology and human tissue culture. The role includes extensive work with human pluripotent stem cells and so previous experience and expertise with CRISPR/Cas9 technologies in addition to laboratory leadership would be an advantage. For example some work will include reprogramming hiPSC derived from patient fibroblasts and retinal organoid cultures. You should be a highly motivated candidate, capable of independently designing and carrying out experiments as well as intellectually contributing to the projects and managing multiple workstreams to achieve their goals in a timely manner. You should be interested in the interface between lab-based research and clinical research and ideally have a track record of publishing in high-quality, peer-reviewed journals.

The vision group investigates various aspects of paediatric and adult eye disease from very clinical projects to lab based and genetic studies in-house with multiple collaborations between PI’s in the vision research group. This role is to support those aspects of projects related to stem cell work. Importantly, this includes regular but minimal weekend maintenance work and covering other staff duties where necessary. Hence, this exciting role offers the opportunity to work at the interphase of cutting-edge, multidisciplinary research on multiple ophthalmic disorders. You will join a vibrant and dynamic research group and be expected to work as a team with other postdocs, PhD/undergraduate students, clinician scientists and technicians as part of the wider vision research group. You will collaborate with colleagues across Faculties of Medicine and Biological Sciences at the University of Southampton and colleagues in other institutions. The candidate can expect a collegial and research-focused environment with mentoring and career development support from the line manager Jorn Lakowski and the other vision groups PI team. 

The post is available for a period of 2 years in the first instance. Interviews for shortlisted candidates are likely to be held in March/April 2026. Informal inquires may be directed to Dr. Jorn Lakowski (J.Lakowski@soton.ac.uk). 

Closing Date: 28 Apr 2026

Section: Technical & Experimental

Salary: £31,236 to £35,608
Full Time Fixed Term (2 Years)

This post holder will work within the paediatric respiratory and allergy research team. They will primarily being undertaking a trial focused on the prevention of childhood asthma. Additionally, they will provide some support to studies focused on preventing food allergy and managing acute severe childhood asthma. The post will provide practical training for a middle grade doctor in the conduct of clinical trials, focussing on supporting clinical trials through all stages including implementation and supporting sites in recruitment, regulatory approvals, data collection and integrity, data presentation and working with translational samples. The post is intended to provide valuable training in research governance and regulation for future clinical and translational researchers. There may be an option to undertake a higher degree.

The appointee will provide day to day medical support for study teams under supervision from Professor Graham Roberts (Professor of Paediatric Allergy and Respiratory Medicine). They will be involved in trial implementation and involvement in study protocol amendments and implementation including ethics committee documentation and R&D submissions. Training in clinical trials methodology including Good Clinical Practice will be provided.

The post will be at registrar level and will require a medical qualification. It would be suitable for a trainee with relevant experience in paediatric medicine as out of program experience or for someone wishing to pursue a career in this specialty prior to obtaining a training number.
 
The post will be a University appointment and does not have any direct clinical work. Duration of post to be discussed with the potential candidate but is 12 months in the first instance. The post is for 0.8FTE, if an applicant wanted a fulltime position, it is expected that this could be arranged - please discuss with Professor Graham Roberts. 

For further information or to arrange an informal discussion about the role, please email Professor Graham Roberts at g.c.roberts@soton.ac.uk.

The Faculty of Medicine holds an Athena SWAN Silver Award demonstrating commitment to equal opportunities and gender balance in the workplace. The Faculty recognises that applicants may seek flexible working patterns which will be considered as part of the recruitment process. For further information including key benefits designed to help maintain and support employees' well-being and work-life balance, please see our working with us website pages. 

Please note: successful applicants will be appointed to a different salary range (£46,675 to £62,502 ) if they were at ST3 on or before 2 August 2016.

Closing Date: 28 Apr 2026

Section: Clinical

Salary: £65,048 Pro rata per annum
Part Time Fixed Term (0.8 FTE until 01/09/2027)

Salary: AMNL £46,675 to £80,081 (for those below ST3 on 3 August 2016); CADT £65,048 to £73,992 (for those at or above ST3 on 3 August 2016),

The Faculty of Medicine wishes to appoint an NIHR Academic Clinical Lecturer, hosted by one of the following clinical specialties: Clinical Genetics, Obstetrics and Gynaecology or General Surgery.

The post is intended for an applicant within any of these three specialities, with the speciality of the final (single) post dependent on the successful applicant.

The post-holder will be pursuing their development of research and teaching within either the Human Development and Health school or Cancer Sciences school of the Faculty of Medicine, University of Southampton. 

In this post-doctoral role, the successful candidate will be in specialist clinical training at ST3 level or above and have substantial experience of the relevant research areas, a proven track record of high-quality original research publications, the ability to work well in a multidisciplinary, multi-professional team and hold a corresponding NTN.

You will join the NIHR Clinical Integrated Academic Training Programme at the University of Southampton, as an NIHR Academic Clinical Lecturer. The post-holder will also have clinical commitments at University Hospital Southampton NHS Foundation Trust that will lead to the acquisition of clinical skills required for full registration within the specialty.

The post is subject to terms and conditions of service determined by the University of Southampton and in its honorary clinical capacity by the University Hospital Southampton Foundation Trust Board.

Informal enquiries are welcome and should be addressed to: 

Clinical Genetics: Professor Diana Baralle, Professor of Genomic Medicine - email: d.baralle@soton.ac.uk 

Obstetrics and Gynaecology: Professor Ying Cheong, Professor of Reproductive Medicine - email: y.cheong@soton.ac.uk

General Surgery: Professor Ramsey Cutress, Professor of Breast Surgery - email: r.i.cutress@soton.ac.uk

A satisfactory Criminal Records Bureau disclosure at Enhanced level is required for this post.  

The Faculty of Medicine holds an Athena SWAN Silver Award demonstrating commitment to equal opportunities and gender balance in the workplace. The Faculty recognises that applicants may seek flexible working patterns which will be considered as part of the recruitment process. For further information including key benefits designed to help maintain and support employees' well-being and work-life balance, please see our working with us website pages.

Closing Date: 08 May 2026

Section: Clinical

Salary: £38,831 to £73,992 per annum
Full Time Fixed Term (4 years full-time, up to 6 years part-time)

The Southampton Clinical Trials Unit (SCTU) is a UK Cancer Research Collaboration (UKCRC) registered unit and was set up in 2006 to design and conduct academically led clinical trials. The Unit employs trial managers, data managers, statisticians, regulatory staff and administrative support staff. We manage a growing portfolio of multi-centre clinical trials that will directly influence routine clinical practice. The Unit is core funded by Cancer Research UK, has support funding from the NHS National Institute for Health Research, and is based at Southampton University Hospitals NHS Trust.

The Role

We have an exciting opportunity to work within the CTU. You will work with other colleagues in a team supporting our trial management team and will take responsibility for providing high quality administrative support across a range of activities.

About You

You will be a team player with a keen eye for detail and a flexible, can-do attitude. You will have excellent IT and inter-personal skills with a commitment to providing excellent customer service. Previous work experience within an administrative or secretarial support role within a research environment is required.

Terms of Appointment

The employing organisation is the University of Southampton which offers a competitive salary, pension scheme and other benefits. The post is offered on a 12 month fixed term contract. This is a full-time post, but part time may be considered.

The CTU is part of a strong research environment in Southampton which includes the Cancer Research UK Clinical Centre, Experimental Cancer Medicine Centre, Welcome Trust Clinical Research Facility and strong NHS R&D Management.

For an informal discussion about this post please contact Nicole Keyworth, Portfolio Lead on n.e.keyworth@soton.ac.uk.

The Faculty of Medicine holds an Athena SWAN Silver Award demonstrating commitment to equal opportunities and gender balance in the workplace. The Faculty recognises that applicants may seek flexible working patterns which will be considered as part of the recruitment process. For further information including key benefits designed to help maintain and support employees' well-being and work-life balance, please see our working with us website pages.

Closing Date: 30 Apr 2026

Section: Management, Specialist & Administrative

Salary: £27,319 to £30,378 Per annum
Full Time Fixed Term for 12 months

We hope to move a compound forward toward Investigational New Drug (IND)-enabling studies and clinical development for severe asthma.

Dr Haitchi’s group studies asthma and in particular the role of the asthma gene ADAM33 in development of asthma using in vivo and in vitro asthma research models.

The posts will be full-time for up to 10 months, funded by a MRC-DPFS grant. 

Candidates must hold or nearing completion of a relevant MSc or PhD qualification (or equivalent). A background in respiratory research with experience in, molecular biology techniques is essential, microscopy and image analysis and animal models is desirable. We especially welcome applications from enthusiastic candidates with prior knowledge of a broad variety of laboratory research methods and human and/or mouse in vivo and ex vivo respiratory disease research models with a keen interest and willingness to learn new research methods as part of a research team in the UK and USA.

We offer an exciting and stimulating work environment. The respiratory research group in CES and the Southampton NIHR-Biomedical Research Centre (BRC) conducts world-class research spanning basic sciences and clinical research for asthma and other lung diseases. The position will be based in the Roger Brooke laboratory.

Besides a great research environment, Southampton and its surrounding provide a beautiful place to live.

More information on the group and BRC:  https://www.southampton.ac.uk/medicine/about/staff/hmha.pageand https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/Facilities/NIHR-Southampton-Biomedical-Research-Centre/NIHRSouthamptonBiomedicalResearchCentre.aspx

Informal enquiries are strongly encouraged and can be made to Dr Hans Michael Haitchi (hmha@soton.ac.uk) - Potential interview dates: April 2026.

The University is committed to equality for all: https://www.southampton.ac.uk/diversity/policies/equal_opportunities.page

Applications for Research Technician positions will be considered from candidates who are working towards or nearing completion of a relevant MSc or PhD qualification.  

Closing Date: 15 Apr 2026

Section: Technical & Experimental

Salary: £31,236 to £39,906
Full Time Fixed Term (until 28/02/2027)

An exciting opportunity is available to join a multidisciplinary research programme across the laboratories of Dr Salah Mansour, Dr Ali Roghanian and Dr Andres Vallejo at the University of Southampton. We are seeking a collaborative and motivated postdoctoral scientist to work on our Blood Cancer UK-funded programme developing next-generation, off-the-shelf immunotherapies for acute myeloid leukaemia (AML).

This three-year project will harness cytotoxic invariant Natural Killer T (iNKT) cells for precision targeting of AML, an aggressive leukaemia with poor survival outcomes. Building on strong preliminary data, it combines mechanistic and translational immunology with bespoke in vivo models to define and exploit therapeutically relevant subsets. The Research Fellow will lead studies on cytotoxic T cell mechanisms, oversee preclinical validation, and advance CAR-iNKT platforms optimised for AML immunotherapy.

The role bridges basic and translational research and suits a creative scientist with interests in tumour immunology, T cell engineering, and immunotherapy. You will join a multidisciplinary team spanning immunology, and bioinformatics, with access to advanced flow cytometry, 10X Genomics, in vivo imaging platforms.

Key responsibilities

• To work within the Mansour and Roghanian labs, and with collaborators at Southampton and beyond.
• To design, conduct, and analyse in vitro and in vivo immunology experiments.
• To lead the optimisation and functional assessment of human T cells and CAR T cells.
• To liaise and coordinate between project collaborators and core facilities.
• To record analyses accurately and present results at group meetings, national, and international conferences.
• To contribute to dissemination of findings through publications and grant applications.
• To supervise and support junior researchers and students.
• Any other duties appropriate to the scope and grade of the post.

Postdoctoral Fellows are expected to lead their own projects, collaborate on others, and guide PhD and Master’s students.

Essential qualifications, experience and competencies

• PhD (or near completion) in human T cell immunology, cancer biology, or a related discipline.
• Strong practical experience with core immunological assays (e.g. FACS, ELISA, T cell assays).
• Proven competence in the design and execution of experiments using mouse models of cancer.
• Ability to manage projects to timelines, supervise junior staff, and work both independently and collaboratively.
• Excellent communication and presentation skills, including at conferences.

Desirable

• Experience with single-cell or bulk sequencing (e.g. 10X Genomics, RNA-seq).
• Familiarity with bioinformatics pipelines and large dataset interpretation.
• Experience in engineering human T cells, viral transduction, or related approaches.
• Home Office Personal Licence.

About us

The University of Southampton offers a strong environment for translational immunology. Clinical and Experimental Sciences (CES) is a hub for infection and immunology, while the Centre for Cancer Immunology (CCI) is the UK’s first dedicated cancer immunology centre. Together, they unite expertise in T cell biology, multiomics, immunotherapy, preclinical modelling, and clinical translation, supported by an embedded Clinical Trials Unit and close links with NHS and industry partners.

Working at the University of Southampton:

Check out the staff benefits and why you should join us at The University of Southampton!

Applicants should provide:

• A CV
• A cover letter outlining suitability for the role
• Contact details for at least two recent referees

Closing Date: 03 May 2026

Section: Education, Research & Enterprise

Salary: £36,636 to £44,746 per annum
Full Time Fixed Term until 31/10/2028

An exciting opportunity is available to join the laboratories of Dr Ali Roghanian and Dr Salah Mansour at the University of Southampton in collaboration with MiNK Therapeutics. We are seeking a collaborative and motivated scientist to work on our new funded programme developing next-generation, off-the-shelf immunotherapies for childhood cancers.

The project will harness engineered cytotoxic invariant Natural Killer T (iNKT) cells for precision targeting of paediatric cancer neoantigens. Building on strong preliminary data, it combines mechanistic and translational immunology with bespoke in vivo models to define and exploit therapeutic candidates. The Research Assistant will lead studies on cytotoxic T cell mechanisms, oversee preclinical validation, and advance TCR-engineered iNKT platforms optimised for immunotherapy.

The role bridges basic and translational research and suits a creative scientist with interests in tumour immunology, T cell engineering, and immunotherapy. You will join a multidisciplinary team spanning immunology, with access to advanced flow cytometry and in vivo platforms.

The funding is initially available for 12 months, with the possibility of extension to 21 months, subject to satisfactory progress.

Key responsibilities

• To work within the Mansour and Roghanian labs, and with collaborators at Southampton, LifeArc and MiNK Therapeutics.
• To design, conduct, and analyse in vitro and in vivo immunology experiments.
• To lead the optimisation and functional assessment of human T cells.
• To liaise and coordinate between project collaborators, including the industrial partner, and core facilities.
• To record analyses accurately and present results at group and collaborative meetings, and conferences.
• To contribute to dissemination of findings through publications and grant applications.
• Any other duties appropriate to the scope and grade of the post.

Essential qualifications, experience and competencies

• Degree (BSc or equivalent) in biological or biomedical sciences or equivalent experience
• Strong practical experience with core immunological assays (e.g., FACS, ELISA, T cell assays).
• Proven competence in the design and execution of experiments using mouse models of cancer.
• Ability to manage projects to timelines, supervise junior staff, and work both independently and collaboratively.
• Excellent communication and presentation skills, including at conferences.

Desirable

• Experience in engineering human T cells, viral transduction, or related approaches.
• Home Office Personal Licence.

About us

The University of Southampton offers a strong environment for translational immunology. Clinical and Experimental Sciences (CES) is a hub for infection and immunology, while the Centre for Cancer Immunology (CCI) is the UK’s first dedicated cancer immunology centre. Together, they unite expertise in T cell biology, multiomics, immunotherapy, preclinical modelling, and clinical translation, supported by an embedded Clinical Trials Unit and close links with NHS and industry partners.

How to apply

Applications must be submitted via the University of Southampton recruitment system by 24th April 2026. Interviews will be held soon after.

Applicants should provide:

• A CV
• A cover letter outlining suitability for the role

Closing Date: 24 Apr 2026

Section: Technical & Experimental

Salary: £36,636 to £37,694 per annum
Full Time Fixed Term for 12 months

An exciting opportunity is available to join the laboratories of Dr Ali Roghanian and Dr Salah Mansour at the University of Southampton in collaboration with MiNK Therapeutics. We are seeking a collaborative and motivated scientist to work on our newly funded programme developing next-generation, off-the-shelf immunotherapies for childhood cancers.

This 12 month project will harness engineered cytotoxic invariant Natural Killer T (iNKT) cells for precision targeting of paediatric cancer neoantigens. Building on strong preliminary data, it combines mechanistic and translational immunology with bespoke preclinical models to define and exploit therapeutic candidates. The Research Technician will lead studies on cytotoxic T cell mechanisms, oversee preclinical validation, and advance TCR-engineered iNKT platforms optimised for immunotherapy.

The role bridges basic and translational research and suits a creative scientist with interests in tumour immunology, T cell engineering, and immunotherapy. You will join a multidisciplinary team spanning immunology, with access to advanced flow cytometry and in vivo platforms.

The funding is initially available for 12 months, with the possibility of extension to 21 months, subject to satisfactory progress.

Key responsibilities

• To work within the Mansour and Roghanian labs, and with collaborators at Southampton, LifeArc and MiNK Therapeutics.
• To design, conduct, and analyse in vitro immunology experiments.
• To lead the optimisation and functional assessment of engineered human T cells.
• To liaise and coordinate between project collaborators, including the industrial partner, and core facilities.
• To record analyses accurately and present results at group and collaborative meetings, and conferences.
• To contribute to dissemination of findings through publications and grant applications.
• Any other duties appropriate to the scope and grade of the post.

Essential qualifications, experience and competencies

• Degree (BSc or equivalent) in biological or biomedical sciences or equivalent experience
• Strong practical experience with core immunological assays (e.g., FACS, ELISA, T cell assays).
• Ability to manage projects to timelines, and work both independently and collaboratively.
• Excellent communication and presentation skills, including at conferences.

Desirable

• Experience in engineering human T cells, viral transduction, or related approaches.

About us

The University of Southampton offers a strong environment for translational immunology. Clinical and Experimental Sciences (CES) is a hub for infection and immunology, while the Centre for Cancer Immunology (CCI) is the UK’s first dedicated cancer immunology centre. Together, they unite expertise in T cell biology, multiomics, immunotherapy, preclinical modelling, and clinical translation, supported by an embedded Clinical Trials Unit and close links with NHS and industry partners.

Application

Applicants should provide:

• A CV
• A cover letter outlining suitability for the role
• Contact details for at least two recent referees

Start date: May 2026 or soon after (negotiable)

Closing Date: 26 Apr 2026

Section: Technical & Experimental

Salary: £36,636 to £37,694 per annum
Full Time Fixed Term for 12 months