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PhD Studentship: Interactions between cancer-associated fibroblasts and immune cells: the role of extracellular matrix

Cancer Sciences

Location:  Southampton General Hospital
Closing Date:  Friday 21 February 2020
Reference:  1237420CM

Lead Institute / Faculty:                    Cancer Sciences Unit/Cancer Centre for Immunology, Faculty of Medicine

Main Supervisor:                                 Professor Gareth Thomas

Other members of the supervisory team:     Dr Natalya Savelyeva, Dr Christopher Hanley, Dr Nadia Luheshi (Astrazeneca)

Duration of the award:      3 years, full time

Project description: 

The Experimental Pathology Group offers a PhD studentship in cancer biology, leading to a PhD degree from the University of Southampton. The project aims to develop new approaches for cancer therapy, and explores the role of the tumour microenvironment in suppressing response to immunotherapy, particularly how cancer-associated fibroblasts inhibit the ability of the immune system to recognise and kill cancer cells. The questions under investigation will require the use of a broad range of cell culture and molecular biology techniques, cell-based functional assays, RNA sequencing and bioinformatics, analysis of human cancers,  and the use of mouse models.   

Please contact:  Professor Gareth Thomas -   g.thomas@soton.ac.uk

Person Specification: See details and link below

We encourage applications from any suitably qualified students (usually with a 1stor 2:1 degree in a relevant discipline and/or second degree with a related Masters).

Funding information:
 
The studentship is funded by Astrazeneca (previously MedImmune) and provides opportunity for secondment to their labs in Cambridge. The studentship is funded for 3 years at UKRC student rates (https://www.uea.ac.uk/study/postgraduate/research-degrees/fees-and-funding/rcuk-pgr-funding; providing approximately £20K/year to cover fees & stipend with an additional budget for laboratory costs). 

Administrative contact and how to apply:

Please complete the University's online application form, which you can find at 

https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=7205&majr=7205&term=201920

You should enter Professor Gareth Thomas as your proposed supervisor. To support your application provide an academic CV (including contact details of two referees), official academic transcripts and a personal statement (outlining your suitability for the studentship, what you hope to achieve from the PhD and your research experience to date).

Informal enquiries relating to the project or candidate suitability should be directed to Professor Gareth Thomas (g.thomas@soton.ac.uk).

Closing date:        21/02/2020

Interview date:     To be confirmed


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