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Research Fellow in Reproductive Biology

Maternal, Fetal & Neonatal Physiology

Location:  Southampton General Hospital
Salary:   £30,942 per annum
Full Time Fixed Term (until 31/05/2022)
Closing Date:  Thursday 19 March 2020
Interview Date:   To be confirmed
Reference:  1241920AF

Applications are invited for a Research Fellow position within the Institute of Developmental Sciences based at Southampton General Hospital. This is an exciting opportunity, offered as a fixed-term contract, to study human endometrial biology in relation to fertility while working closely with an interdisciplinary team including biologists, clinicians and engineers.

Project Overview: Problems with endometrial receptivity can lead to recurrent implantation failure, subfertility or miscarriage. Improving pregnancy success in these women requires increased understanding of the endometrium at the molecular level. The overall aim of the project is to identify factors in the endometrium that impede or facilitate implantation and successful pregnancy.

The successful candidate will use endometrial samples from healthy woman or those with subfertility or miscarriage. The project will use single-cell sequencing (Drop-Seq) alongside 3D imaging techniques to generate a unique understanding of how different endometrial cell types relate. The gene signature for each individual cell type will be applied to interpret transcriptomic data from whole endometrial samples in our clinical cohorts. By adjusting for variation in cell types within the tissue sample, we hope to achieve a robust gene signature associated with endometrial receptivity and likely pregnancy success. 

We are looking for applicants with a PhD* in biological sciences or bioengineering. Experience with physiological preparations and handling large data sets or bioinformatics analysis is essential, as is the ability to work flexible hours. Knowledge of molecular techniques, microscopy and single-cell gene sequencing from cell sample preparation and microfluidic device fabrication through to sequencing, running the bioinformatics pipeline and downstream analysis is desirable.

*Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification.  The title of Research Fellow will be applied upon successful completion of the PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.

This post is available from 01/06/2020 until 31/05/2022. Informal enquiries may be made to Dr Jane Cleal (j.k.cleal@soton.ac.uk) or Professor Rohan Lewis (r.m.lewis@soton.ac.uk).

Application procedure:

You should submit your completed online application form at www.jobs.soton.ac.uk. The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Kate Pounds (Recruitment Team) on +44 (0) 23 8059 5456. Please quote reference 1241920AF on all correspondence.

The Faculty of Medicine holds an Athena SWAN Silver Award demonstrating commitment to equal opportunities and gender balance in the workplace. The Faculty recognises that applicants may seek flexible working patterns which will be considered as part of the recruitment process. For further information including key benefits designed to help maintain and support employees' well-being and work-life balance, please see our working with us website pages.

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

Further details:

We aim to be an equal opportunities employer and welcome applications from all sections of the community. Please note that applications from agencies will not be accepted unless indicated in the job advert.


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