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CRUK ECRIN-M3 Senior Research Fellow in B-cell Cancer Bioinformatics

Cancer Sciences

Location:  Southampton General Hospital
Salary:   £39,152 to £44,045 per annum
Full Time Fixed Term (30/06/2025)
Closing Date:  Wednesday 05 August 2020
Interview Date:   To be confirmed
Reference:  1275220CM

The School of Cancer Sciences in Southampton, with over 100 scientists, clinicians and associated staff, has a long and distinguished record in the study of Cancer. 

We are now seeking a senior research scientist to investigate single-cell gene expression and chromatin accessibility in normal and malignant immune cells, as part of the CRUK Accelerator grant ‘Early Cancer Research Initiative Network on Monoclonal B-cell Lymphocytosis (ECRIN-M3), awarded to Dr Francesco Forconi with Professor Jonathan Strefford. The candidate will work as part of a multi-disciplinary team investigating the biology of early-stage mature B-cell neoplasms. The successful candidate will analyse next-generation sequencing (NGS)-based expression and ATAC-seq data, at the bulk and single-cell level, with subsequent downstream modelling and molecular studies. The ultimate aim will be to identify and functionally characterize expression patterns determining progression to overt leukaemia, highlighting potential cancer biomarkers.

The successful candidate will have extensive bioinformatics experience working on genomic, transcriptomic of epigenomic NGS data sets, including experience of high-level data integration. The successful candidate will work within a dynamic, productive and friendly team of geneticists, bioinformaticians and, molecular/cellular biologists and clinical scientists within the ECRIN-M3 programme and across the School of Cancer Sciences based at Southampton General Hospital. This project offers the opportunity to develop a wide range of NGS and bioinformatics and provides the prospect of collaborative work with national and international opinion-leaders in the areas of computational methods for the analysis of high-throughput RNA and ATAC-seq data. Your work will have important implications for the clinical management of patients, including the development of better methods of patient stratification.

This post will be based within the Cancer Research UK Centre and Centre for Cancer Immunology at the Southampton General Hospital campus, occupying modern, well-equipped, purpose-built laboratories, with support from clinical and laboratory-based colleagues. 

The position is funded by Cancer Research UK and is full-time, fixed-term to June 2025 in the first instance with full duration expected to be 60 months, subject to continued funding.

Interviews will be held on the 8th and 9th of September.

Additional details about the School of Cancer Sciences can be found at

Informal queries should be directed to Professor Jonathan Strefford ( and/or Dr Francesco Forconi ( Please quote reference numbers 1275220CM on all correspondence.

Application Procedure: 

You should submit your completed online application form at The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Kate Pounds (Recruitment Team) on +44 (0) 23 8059 5456. Please quote reference 1275220CM on all correspondence.

The Faculty of Medicine holds an Athena SWAN Silver Award demonstrating commitment to equal opportunities and gender balance in the workplace. The Faculty recognises that applicants may seek flexible working patterns which will be considered as part of the recruitment process. For further information including key benefits designed to help maintain and support employees' well-being and work-life balance, please see our working with us website pages.  

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

Further details:

We aim to be an equal opportunities employer and welcome applications from all sections of the community. Please note that applications from agencies will not be accepted unless indicated in the job advert.

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