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Research Fellow in Oocyte Cell Biology

Biomedicine

Location:  Highfield Campus
Salary:   £29,301 to £31,076
Full Time, Fixed Term (3 Years)
Closing Date:   Monday 27 February 2017
Interview Date:   Tuesday 07 March 2017
Reference:  831017BJ

Applications are invited for a Postdoctoral Research Fellow to join Professor Keith Jones’ research group for a BBSRC funded grant, to study the effects of DNA damage on mammalian oocytes. For this post a PhD in any aspect Biological Sciences or equivalent professional qualification and a detailed understanding and knowledge of cell biology is required. Any experience in intracellular imaging techniques (such as confocal microscopy), cell cycle control, DNA damage, and mammalian oocyte handling are advantageous.

Brief description of the project: Oocytes mature to become fully grown eggs that are capable of creating a viable embryo at fertilization. Unfortunately often 30%, or greater, of mammalian oocytes fail to produce fully mature eggs. Instead they arrest at a specific point in their maturation, during a stage of meiosis that is only a couple of hours before ovulation. It has never been investigated as to why oocytes fail to mature and so arrest at this specific meiotic timepoint. This is surprising given such a block is likely to be physiologically relevant in preventing the creation of poor quality eggs. This project will investigate the role of DNA damage in this arrest, and its ability to engage the Spindle Assembly Checkpoint - a universal cell cycle checkpoint responsible for preventing chromosome mis-segregation.  

 Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon completion of PhD.  Prior to the qualification being awarded the title of Senior Research Assistant will be given. Part-Time applications will be considered.

The post is available from 3rd April 2017 for a period of 3 years. Informal inquiries are welcome, and can be made to Prof Keith Jones (k.t.jones@soton.ac.uk).

Application Procedure:

You should submit your completed online application form at www.jobs.soton.ac.uk. The vacancy will close at midnight on the closing date as shown above. If you need any assistance, please contact Anastasia Shikhareva on +44 (0) 23 8059 9002. Please quote vacancy reference number 831017BJ on all correspondence.

Biological Sciences holds an Athena Swan Bronze Award, demonstrating their commitment to providing equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine.  Biological Sciences is able to provide flexible working opportunities in a part-time and due consideration will be given to applicants who have taken a career break.The University has a generous maternity policy, onsite childcare facilities and employees are able to participate in the childcare vouchers scheme. Other benefits include state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.

Athena SWAN Bronze Award holder: Centre for Biological Sciences

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

Further details:

We aim to be an equal opportunities employer and welcome applications from all sections of the community. Please note that applications from agencies will not be accepted unless indicated in the job advert.


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