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Research Fellow - Microscopy analyses of antibody-based therapeutics

Cancer Sciences

Location:  Southampton General Hospital
Salary:   £30,942 to £38,017
Full Time Fixed Term (36 Months)
Closing Date:  Wednesday 04 December 2019
Interview Date:   To be confirmed
Reference:  1198919CM

The position will be held in the Centre for Cancer Immunology at Southampton General Hospital.  This is a newly constructed, dedicated research building that is the result of a significant fund-raising campaign. It builds on a 40 year history of pioneering immunology and cancer research at Southampton, and represents the first dedicated cancer immunology centre in the UK. The activities in this centre span from pioneering discovery science to applied research and preclinical modelling and, crucially, onto first-in-human clinical trials and beyond.  The centre houses world-class research facilities, including state-of-the-art scientific laboratories and a clinical trials unit.

The position is associated with the laboratory of Professors Ward and Ober who are relocating their research group from the USA to Southampton. Their interdisciplinary research program is dedicated to the development of novel antibody-based therapeutics that in the past has led to several therapeutics that are currently in late-stage clinical trials. The group also develops advanced microscopy techniques for the evaluation of novel therapeutics in cellular environments. Their research is supported by major grants from the Wellcome Trust, Cancer Research UK and collaborations with biopharma companies.

Over recent decades the research group has pioneered several new microscopy approaches, in particular single molecule technologies, such as multifocal plane microscopy for the study of three-dimensional subcellular dynamics of therapeutic proteins. The post-holder will be a member of a large multidisciplinary research group that develops and applies advanced microscopy techniques to address questions of biological interest. Specifically, the projects will involve the use of live cell imaging to analyse the subcellular trafficking behaviour of antibody-based therapeutics, with the goal of generating novel approaches to treat cancer and autoimmunity. A particular focus of this work will be to characterise endo-lysosomal trafficking properties in live cells.

The appointee will be highly motivated and excited by the challenges involved in the imaging of engineered proteins that are of therapeutic relevance and of interest to bioopharma. The appointee is expected to have an outstanding background, including high quality publications, in the use of advanced fluorescence microscopy techniques. An understanding of antibody biology and/or antibody-based therapeutics is desirable but not essential. 

Scientific knowledge in the areas described above equivalent to PhD*. level is required. The post-holder will possess relevant academic qualifications and work experience as well as good IT skills.  Non-UK/non-EU citizens are also welcome to apply.

*Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification.  The title of Research Fellow will be applied upon successful completion of the PhD.Prior to the qualification being awarded the title of Senior Research Assistant will be given.

The position is for three years. Availability of funds for a period beyond the three year time frame is anticipated.

Informal enquiries should be directed to Professor E. Sally Ward (e.sally.ward@gmail.com) or Professor Raimund J. Ober (raimund.ober@gmail.com).

Application Procedure:

You should submit your completed online application form at www.jobs.soton.ac.uk. The vacancy will close at midnight on the closing date as shown above.

References are requested along with your application. This reference system is automated so please ensure you provide the correct email address and allow time for these to be received, prior to the close date, to assist the department with shortlisting.

If you need any assistance, please call Charlene Tyson (Recruitment Team) on +44 (0) 23 8059 6803. Please quote reference 1198919CM on all correspondence.

The Faculty of Medicine holds an Athena SWAN Silver Award demonstrating commitment to equal opportunities and gender balance in the workplace. The Faculty recognises that applicants may seek flexible working patterns which will be considered as part of the recruitment process. For further information including key benefits designed to help maintain and support employees' well-being and work-life balance, please see our working with us website pages.

Athena SWAN Silver Award holder: MedicineCancer Research UK

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We aim to be an equal opportunities employer and welcome applications from all sections of the community. Please note that applications from agencies will not be accepted unless indicated in the job advert.


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