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Alzheimer’s Society funded PhD Studentship – Investigating the role of tauopathy-induced activating transcription factor 3: a transcriptional hub to modulate neurodegeneration.

Neuroscience

Location:  Highfield Campus
Closing Date:  Friday 28 February 2020
Reference:  1212919BJ

PhD Supervisor: Katrin Deinhardt                         co supervisor: Vincent O’Connor


PhD Description:  

Fully funded PhD position available to study the role of ATF3 in tau-mediated neurodegeneration. We have previously identified an upregulation of the transcription factor ATF3 in mouse models of neurodegeneration. While ATF3 has been shown to have a protective role in motor neurons, little is known about its function within the brain. This studentship will use cell biological and biochemical approaches to investigate the effects of ATF3 expression in primary neurons at early stages of tauopathy. Understanding the mechanisms that underlie the neurodegeneration found in dementias is an important route to finding therapies for these diseases.

The project is funded for 3 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. Funding will cover fees and a stipend at current research council rates of £ 15,009 per annum for 2019/20. Subject to rise for 2020/21.

Due to funding restrictions this position is only open to UK/EU applicants

Applications for an MPhil/PhD in Biological Sciences should be submitted online at:

https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=4973&majr=4973&term=201920  Please place Katrin Deinhardt’s name in the field for proposed supervisor.

General enquiries should be made K.Deinhardt@soton.ac.uk.  Any queries on the application process should be made to fels-pgr-apply@soton.ac.uk.

Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified.

The University of Southampton and the School of Biological Sciences both hold an Athena Swan Silver Award, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine.  Due consideration will be given to applicants who have taken a career break. University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.

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