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Research Fellow

Respiratory

Location:  Southampton General Hospital
Salary:   £30,942 to £32,817 Pro rata per annum
Part Time Fixed Term (2 years)
Closing Date:  Friday 21 February 2020
Interview Date:   Tuesday 25 February 2020
Reference:  1244720FC

University of Southampton 3TR Research Fellow 

Are you a successful researcher with specific expertise in systematic analysis? We are looking for an experienced researcher to join our University of Southampton Faculty of Medicine group. The overall goal of the project is to be able to predict response to biological therapy on the basis of ‘omic results. This part of the project aims to understand the important, patient-centred outcomes in asthma and chronic obstructive pulmonary disease (COPD) and their responsiveness to biological therapies.

The successful candidate must have a PhD* / equivalent professional qualifications or MSc and experience in systematic reviews. The candidate should have a good publication record. There will be an opportunity to supervise PhD or MSc students.

The overall consortium is called “Taxonomy, Treatment, Targets and Remission (3TR): Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions”. It is a seven year, pan-European project funded by the European Union Innovative Medicine programme. The Southampton leads are Professor Graham Roberts and Prof Ratko Djukanovic who are based in the Faculty of Medicine.

Airway diseases such as asthma and COPD are common, chronic and collectively impose a substantial healthcare burden. While treatments are available, response and disease progression is unpredictable in individual patients. Molecular profiling and integration of multi-omics data is a novel approach to stratify individuals with clinically heterogeneous diseases into groups with a similar molecular basis of their pathogenesis. 3TR is a highly integrated and transdisciplinary European consortium that plans multi-dimensional molecular (‘omic) analysis of multiple sample types collected longitudinally from homogeneously recruited patient cohorts suffering from seven different autoimmune, allergic and inflammatory diseases. This high-resolution multi-omics analysis of individualised disease trajectories will facilitate the stratification and identification of molecular patterns that better predict response or non-response to therapy. The major aim of the consortium is to identify solid biomarker signatures as well as molecular pathways and mechanisms linked to response and non-response to therapy.

The Southampton part of this project focuses on the determination of therapeutic response in asthma and COPD looking at clinical, biological and patient reported outcomes. The first part will involve the identification of relevant biomarkers in asthma and COPD - clinical, biological and imaging aspects. It will use a systematic review – GRADE approach. The second part will focus on assessing the patient centeredness of existing patient reported outcomes and quality of life measurements in asthma and COPD, working with patient organisations. The third part focuses on the definition of response with asthma COPD therapies and will build on existing definitions.

Your role would firstly be to plan, coordinate and participate in the delivery of the Southampton components of the 3TR project. You will lead on the systematic review work, working closely with a 3TR PhD student based in Southampton. You would support their studies. The project will involve liaison with project partners from across Europe.

The position is fixed term, 0.5 full-time equivalent over two years although there is flexibility in how these hours are spread over this time within the needs of the project

For further information please contact Professor Graham Roberts (g.c.roberts@soton.ac.uk). 

*Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification.  The title of Research Fellow will be applied upon successful completion of the PhD.  Prior to the qualification being awarded the title of Senior Research Assistant will be given.

Application Procedure: 

You should submit your completed online application form at https://jobs.soton.ac.uk. The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Kate Pounds (Recruitment Team) on +44 (0) 23 8059 5456. Please quote reference 1244720FC on all correspondence.

The Faculty of Medicine holds an Athena SWAN Silver Award demonstrating commitment to equal opportunities and gender balance in the workplace. The Faculty recognises that applicants may seek flexible working patterns which will be considered as part of the recruitment process. For further information including key benefits designed to help maintain and support employees' well-being and work-life balance, please see our working with us website pages.

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We aim to be an equal opportunities employer and welcome applications from all sections of the community. Please note that applications from agencies will not be accepted unless indicated in the job advert.


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