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Dissecting the mechanisms that underpin tau pathology propagation

School of Biological Sciences

Location:  Highfield Campus
Closing Date:  Saturday 14 August 2021
Reference:  1429821BJ

PhD Supervisor: Amrit Mudher                            co supervisor: Douglas Alan/Herman Wijnen

Interviews will be held in by 31st Aug 2021 via teams

PhD Description

Tau pathology spreads throughout the brains of tauopathy patients by a process often described as “prion-like” propagation. The mechanisms that underpin this pathogenic spread are unclear, though this is an intensely researched area, with data emerging from several in vitro and in vivo experimental paradigms. This PhD project offers an exciting opportunity to identify critical modulators of spread in an unbiased screen using a novel Drosophila model of tau propagation. The student will acquire expertise in several experimental techniques, including confocal microscopy, in vivo imaging, immunohistochemistry, and Drosophila genetics. As this is a collaboration between the University of Southampton and the University of British Columbia (UBC), there will be a period of secondment to UBC, providing further opportunities for training and networking in the Allan laboratory. As well as this, the student will benefit from exposure and training through collaboration with two groups with expertise relevant to this project: Dr Herman Wijnen and Dr Katrin Deinhardt (University of Southampton, UK).

Due to funding restrictions this position is only open to UK applicants

Applications for a PhD in Biological Sciences should be submitted online at:

please place Name in the field for proposed supervisor.  

General enquiries should be made Amrit Mudher on 

Any queries on the application process should be made to

Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified.

The University of Southampton and the School of Biological Sciences both hold an Athena Swan Silver Award, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine.   Due consideration will be given to applicants who have taken a career break.  University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.

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