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PhD studentship - Identification and development of cyclic peptide inhibitors of the Myc oncogenic transcription factor

Chemical Biology, Diagnostics & Therapeutics

Location:  Highfield Campus
Closing Date:  Thursday 30 September 2021
Reference:  1467721EB

Project title:                 Identification and development of cyclic peptide inhibitors of the Myc oncogenic transcription factor

Supervisory Team:    Prof Ali Tavassoli

Project description

We are seekign an outstanding applicant to work on an industrially-sponsored chemical biology project to identify and develop inhibitors of an oncogenic transcription factor. 

Overexpression of Myc proteins is a hallmark of many cancers. Myc proteins are transcription factors that markedly alter gene expression through both activation and repression of transcription, thus regulating a wide range of biological processes including proliferation and playing a driving role in neoplastic transformation. In this project, we will use a genetically-encoded cyclic peptide library in combination with a cell-based reporter to identify inhibitors of this protein-protein interaction. 

The project provides an excellent opportunity to receive high-quality training in a range of techniques at the chemistry/biology interface. The project will be conducted in the Tavassoli lab, in close collaboration with Curve Therapeutics, using state of the art multidisciplinary laboratories, facilities and equipment. This project provides a unique opportunity to work closely with a biotechnology company on a drug discovery project. 

The ideal candidate will have prior lab-based experience of chemical biology, cell culture and/or synthetic organic chemistry. However, experience in all these areas isn’t essential, and appropriate training will be provided to the successful candidate as part of their PhD. 

More information about the Tavassoli lab can be found on the University of Southampton website:

https://www.southampton.ac.uk/chemistry/about/staff/ali1.page 

If you wish to discuss any details of the project informally, please contact Ali Tavassoli, Email: ali1@soton.ac.uk

Entry Requirements

A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent).

Closing date: applications should be received no later than 30 September 2021 for standard admissions, but later applications may be considered depending on the funds remaining in place.

Funding: For UK students, Tuition Fees and a stipend of £15,609 tax-free per annum for up to 3.5 years. 

How To Apply

Applications should be made online. Select programme type (Research), 2021/22, Faculty of Physical Sciences and Engineering, next page select “PhD  Chemistry (Full time)”. In Section 2 of the application form you should insert the name of the supervisor Ali Tavassoli 

Applications should include

Curriculum Vitae

Two reference letters

Degree Transcripts to date

Apply online: https://www.southampton.ac.uk/courses/how-to-apply/postgraduate-applications.page

 

For further information please contact: feps-pgr-apply@soton.ac.uk 

 

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