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Senior Research Assistant/Research Fellow in Biomedical Signal Processing

Signal Processing & Control Group

Location:  Highfield Campus
Salary:   £27,854 to £34,223
Full Time, Fixed Term (3 years)
Closing Date:   Friday 15 November 2013
Interview Date:   Monday 16 December 2013
Reference:  297913KR

Applications are invited for the post of Senior Research Assistant/Research Fellow in Biomedical Signal Processing, to work on the project Diversity in blood flow control to the brain: moving from individualized modelling towards personalized treatment of the injured brain, funded by the UK’s Engineering and Physical Sciences Research Council (EPSRC) in a collaboration with the Universities of Oxford and Leicester (UK).

The post will be based in the Institute of Sound and Vibration Research / Faculty of Engineering and the Environment at the University of Southampton, and is led by Dr. D. Simpson.  The project will be carried out in close cooperation with University Hospital Southampton Foundation Trust (Dr. T. Birch and Mr. D. Bulters).

Blood flow to the brain in controlled by a series of interacting complex physiological mechanisms that ensure an adequate supply at all times. Of particular interest in this project is the control of flow in response to changes in blood pressure, generally known as ‘cerebral autoregulation’, whose dysfunction has been associated with many clinical conditions, from prematurity in babies to dementia, head-trauma and stroke. Methods to assess autoregulation in patients still present many challenges, but usually involve simultaneous monitoring of blood flow (from Doppler ultrasound) and blood pressure, as well as other physiological variables. Mathematical modelling of the interaction using linear or non-linear and time-invariant or adaptive filters can then provide measures of regulatory activity. In the current project this will be extended in order to probe differences in control strategy adopted by different individuals, both healthy and impaired. The range of effective strategies adopted by healthy subjects is expected to provide a better definition of what is ‘normal’ and hence allow improved detection of impairment. This has the potential to then allow optimization of patient management, especially after stroke.

The tasks of the Research Fellow will be primarily to develop, test, optimize and apply signal analysis methods (based primarily on system identification) to assess autoregulation, and hence describe diversity in autoregulation observed. In addition he/she will support data collection from healthy subjects and patients at Southampton General Hospital, and support management, outreach and dissemination activities. The work will involve close interaction with the Universities of Oxford (Dr. S. Payne, whose will investigate the interaction between cerebrovascular and cardiovascular control) and Leicester (Profs. T. Robinson and R. Panerai, whose focus is the assessment of stroke-patients).

Candidates should have a PhD in Signal Processing / Mathematical Modelling or closely related discipline, and strong experience of working with biomedical signals, preferably related to the brain and/or blood-flow. The post has a duration of 3 years, and will start late 2013 / early 2014. 

Informal enquiries may be made to Dr. David Simpson (ds@isvr.soton.ac.uk).

Application Procedure:

The closing date for this post is 15 November 2013. You should submit your completed online application form at www.jobs.soton.ac.uk. If you require any assistance, please call +44 (0)23 8059 2507. Please quote reference 297913KR on all correspondence.

 

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

Further details:

We aim to be an equal opportunities employer and welcome applications from all sections of the community. Please note that applications from agencies will not be accepted unless indicated in the job advert.



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