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Research Fellow in Cell Biology
Molecular & Cellular
Full Time, Fixed Term (2 years)
Thursday 23 February 2017
To be confirmed
Applications are invited for an enthusiastic Postdoctoral Research Fellow to join Dr Tumbarello’s research group to lead an exciting project funded by the Wellcome Trust that aims to understand the cellular mechanisms that regulate a selective autophagic pathway, called mitophagy. We are looking to recruit a PhD or equivalent professional qualification in Biological Sciences with a thorough understanding of cell biology, with a keen interest in membrane trafficking pathways, experience in cell culture, and ideally experience in CRISPR-Cas9 gene editing, biochemistry, and/or microscopic imaging. Knowledge of autophagy and experience with primary cell culture, confocal microscopy, and molecular biology is beneficial.
Southampton University is a world leading research university and Russell group member with 97% of its research work assessed as world leading and internationally excellent in the REF 2014 assessment. We have an international reputation for research, teaching and enterprise activities, which impact on government policy making, health issues, and on business.
The work will take place at the main University campus, in Building 85, which was recently constructed (2008; £47M) to house Biological Sciences researchers and those who conduct multidisciplinary research in any aspect of life sciences.
This research study aims to investigate the mechanisms that regulate a crucial, selective autophagic pathway essential for maintaining mitochondrial homeostasis and cell health. This will involve analysis of a multifunctional protein complex that regulates cargo sorting, cell signalling, and vesicle trafficking, which has been tentatively implicated in associating with and modulating major mitophagy regulators. This project will utilise CRISPR-Cas9 gene editing approaches, as well as biochemical and advanced imaging techniques to investigate the cellular role of this protein complex and its molecular mechanisms during early events following mitophagy induction. The outcomes of this research will inform us of crucial mechanisms during an essential physiological process and investigate its association with a variety of pathologies, from Parkinson’s to cardiomyopathies. The applicant should have expertise in cell biology and knowledge of membrane trafficking pathways and ideally selective autophagy.
This post is suitable for cell biologists and biomedical scientists with a strong background in molecular biology, biochemistry, cell culture, and cellular imaging, and is available now.
Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon completion of PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.
For additional information/informal enquiries before submitting your application, contact Dr David A Tumbarello, D.A.Tumbarello@soton.ac.uk.
You should submit your completed application form online at www.jobs.soton.ac.uk. The application deadline will be midnight on the closing date stated above. References are requested along with your application, so please allow time for these to be received prior to the close date, to assist the department with shortlisting. If you need any assistance, please call Anna Shikhareva (Recruitment Team) on +44 (0) 23 8059 9002. Please quote vacancy reference number 829917BJ on all correspondence.
Please include a covering letter and full CV in your application.
We aim to be an equal opportunities employer and welcome applications from all sections of the community. Please note that applications from agencies will not be accepted unless indicated in the job advert.